WCA | Toxicology and Human Health Risk Assessment

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Society strives for sustainable, safe use of chemicals, materials and devices. Establishing what amount of chemical is consistent with a risk to human health, requires a robust understanding of potential exposure scenarios along with absorption, distribution and metabolism characteristics of the chemical and ultimately its toxicology. In addition to the expertise of wca in the derivation and implementation of thresholds of adverse effects for the environment, wca also has considerable expertise in the compilation of data from comprehensive in vitro and in vivo regulatory testing programmes and their application in a wide range of human health risk assessments.

Service areas: Toxicology & Human Health Risk Assessment,

Human Health Risk Assessment

The ubiquity of unintentional human exposure to chemicals, via food, water, consumer products and household agents, as well as intentional exposure via therapeutic agents, continues to fuel growing concern regarding the potential health threats. wca combine expertise in human health risk assessment, toxicology, adverse outcome pathways (AOP), exposure and chemistry to solve novel problems.

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Service areas: Toxicology & Human Health Risk Assessment,

Mode and Mechanism of Action

Regulatory agencies primarily rely on toxicological science to identify potential hazards, prioritise chemicals and other potentially toxic substances, and provide the data for assessing risk. However, advances in analytical techniques and increased understanding of Adverse Outcome Pathways (AOPs) have led to significant changes in the recommended approaches to chemical safety assessment, emphasising the importance of the mechanism and mode of action.

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Service areas: Toxicology & Human Health Risk Assessment,

Toxicity Profiles

wca review and critically evaluate toxicological data on a wide range of chemicals to produce an expert opinion on the associated risks. wca have been involved in many hundreds of successful registrations for the first major REACH registration deadlines of 2010, 2013 and 2018. In addition, wca have evaluated large volumes of regulatory toxicology and published toxicological data in the evaluation of endocrine disruptor potential, evaluation of the toxicological hazard of extractables, leachables , and contaminants and the conduct of human health risk assessments in a variety of exposure scenarios.

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Service areas: Toxicology & Human Health Risk Assessment,

Study Design, Monitoring and Interpretation

wca have extensive experience in establishing and monitoring in chemico, in vitro and in vivo studies, including selecting relevant Contract Research Organisations (CRO), review of study plans, discussion with the relevant laboratories as the studies progress and review of draft reports.

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PDE assessments

The possibility of contaminating medicinal products with other potentially active moieties is an ever-increasing risk in the production and use of pharmaceutical products. There appears to be a growing practice of manufacturing different medicinal products in shared facilities presenting the potential for cross contamination. Also, the occurrence of chemicals leaching from materials in contact with medicinal or food products is also recognised as a potential hazard to users of medical devices and in the packaging of various foods. ICH legislation covers the assessment of this risk and the setting of permitted daily exposure of such chemicals.

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