wca review and critically evaluate toxicological data on a wide range of chemicals to produce an expert opinion on the associated risks.

wca have been involved in many hundreds of successful registrations for the first major REACH registration deadlines of 2010,2013 and 2018. In addition, wca have evaluated large volumes of regulatory toxicology and published toxicological data in the evaluation of endocrine disruptor potential, evaluation of the toxicological hazard of extractables, leachables, and contaminants and the conduct of human health risk assessments in a variety of exposure scenarios.

Regulatory agencies primarily rely on toxicological science to identify potential hazards, prioritise chemicals and other potentially toxic substances, and provide the data for assessing risk. However, continued advances in non-animal alternatives have led to significant changes in the recommended approaches to chemical safety assessment. In the assessment of hazard and risk of a range of active ingredients, wca routinely conduct extensive literature reviews, explore Quantitative Structure Activity Relationships (QSAR) and identify/justify the use of suitable read-across substances. In addition to international test guidelines, wca have extensive experience in non-animal in silico and in vitro testing batteries that aim to elucidate the mechanism and mode of toxicity.

Examples of projects:

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