All Services
Society strives for sustainable, safe, use of chemicals and materials. Establishing what amount of chemical is consistent with a risk to ecological quality or human health, requires a robust understanding of chemical fate, ecotoxicity and toxicology. wca are experts in the derivation and implementation of thresholds of adverse effects for the environment and human health and their use in risk or compliance assessment.
Service areas: Toxicology & Human Health Risk Assessment,
Human Health Risk Assessment
The ubiquity of human exposure to chemicals, via food, water, consumer products and household agents, has led to growing concern regarding the potential health threats. wca combine expertise in human health risk assessment, toxicology, adverse outcome pathways (AOP), exposure and chemistry to solve novel problems.
Service areas: Toxicology & Human Health Risk Assessment,
Mode and Mechanism of Action
Regulatory agencies primarily rely on toxicological science to identify potential hazards, prioritise chemicals and other potentially toxic substances, and provide the data for assessing risk. However, recent advances in non-animal alternatives have led to significant changes in the recommended approaches to chemical safety assessment, emphasising the importance of the mechanism and mode of action.
Service areas: Toxicology & Human Health Risk Assessment,
Toxicity Profiles
wca review and critically evaluate toxicological data on a wide range of chemicals to produce an expert opinion on the associated risks. wca have been involved in over 400 successful registrations for the first two major REACH registration deadlines (2010 and 2013) and continue to work towards a number of 2018 substance registrations.
Service areas: Toxicology & Human Health Risk Assessment,
Study Design, Monitoring and Interpretation
wca have extensive experience in establishing and monitoring in chemico, in vitro and in vivo studies, including selecting relevant Contract Research Organisations (CRO), review of study plans, discussion with the relevant laboratories as the studies progress and review of draft reports.
PDE assessments
The possibility of contaminating medicinal products with other potentially active moieties is an ever-increasing risk in the production and use of pharmaceutical products. There appears to be a growing practice of manufacturing different medicinal products in shared facilities presenting the potential for cross contamination.