Service areas: PharmaceuticalsToxicology & Human Health Risk Assessment,

Risk Assessment of Multiple Extractables from Components of an MDI

Metered Dose Inhalers (MDIs) are manufactured from a variety of plastic or rubber materials, and over time leaching into the active substance can occur. We undertook a risk assessment to estimate risk to human health from exposure to the MDI leachables.
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Service areas: Pharmaceuticals,

Risk Assessment of HFAs used as Propellants in Autoinjector systems

We undertook a risk assessment of hydrofluoroalkanes (HFAs) exposed intradermally or subcutaneously during autoinjection in humans using a medical device. As exposure to HFAs via this pathway is uncommon, data from other exposure pathways were considered, taking into account metabolic pathways and local and systemic effects.
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