August 4, 2010 by Mark Crane

We are presenting the results of the Defra-funded inchemicotox project on alternatives to animal testing in chemical risk assessment at a one-day workshop on the 17th of September 2010. The workshop is free to attend and will be held at the Leeds Royal Armouries Museum. The workshop will follow on directly from the 2nd International Lhasa symposium on New Horizons in Toxicity Prediction which also takes place at the Leeds Royal Armories Museum between the 15th and 16th of September, 2010.

The inchemicotox project has produced the following outputs, which will be described and demonstrated at the workshop:

1. Quality assured databases have been provided for the regulatory endpoints skin sensitisation and acute fish toxicity.

2. Robust QSARs have been developed for narcotic mechanisms of action for acute fish toxicity. QSAR Model Reporting Formats have been created. The use of grouping and read-across has been shown for the prediction of skin sensitisation.

3. The in vitro components of an Intelligent Testing Strategy have been identified. These are supported by methods to extrapolate information from in vitro data.

4. In chemico information has been created that supports assigning a compound to a reactive mechanism of action. The reactive mechanisms assist in grouping together compounds that act as skin sensitisers and help to identify non-narcotic compounds.

5. A tool has been created to guide users through assessing the information within an Intelligent Testing Strategy. This enables them to make evidence-based decisions to assess toxicity.

6. Intelligent Testing Strategies have been developed for fish acute toxicity and skin sensitisation to enable appropriate decisions for risk and hazard assessment. These strategies build on the components developed in this project and provide the user with a flexible solution to using non-test data.

The workshop will be of interest to colleagues from regulatory agencies, industry, consultancy and NGOs who need to use QSARs and other non-testing methods under REACH and other European chemicals directives.

Attendance at the workshop is free of charge, but places are limited. Please contact us if you wish to attend. A detailed agenda, further background information, and a location map will be provided to all registrants in early August.