September 16, 2010 by Mark Crane

We have worked with our collaborators to produce a new website which presents the results from a four-year Defra project on Alternatives to Animal Testing.

The following tasks were completed:

  • Toxicological information for skin sensitisation and fish acute toxicity were collated. This information was obtained from the open literature (including a variety of internet sources) and was supplemented with information from European Union and other National and International Projects.
  • In silico tools, such read-across and (quantitative) structure-activity relationships (Q)SARs were developed further for the prediction of reactive toxicity (e.g. excess acute fish toxicity, skin sensitisation).
  • In vitro methods and the use of surrogate (lower) species were evaluated for the successful prediction of toxicological effects. This included the development of the use of surrogate species (such as the TETRATOX and Microtox tests). Prediction Models (PMs) to extrapolate information from a lower species (such as a microorganism) to a higher species (such as a vertebrate) were developed.
  • Mechanisms of toxic action for skin sensitisation and acute fish toxicity were determined. This included the extension of existing approaches based on chemical reactivity to make them suitable for integration into the testing strategies.
  • Integrated testing strategies for risk assessment developed here and elsewhere e.g. the REACH Implementation Projects (RIPs), EU 6th Framework Integrated Projects etc. were assessed.