wca review and critically evaluate toxicological data on a wide range of chemicals to produce an expert opinion on the associated risks. wca have been involved in over 400 successful registrations for the first two major REACH registration deadlines (2010 and 2013) and continue to work towards a number of 2018 substance registrations.
Regulatory agencies primarily rely on toxicological science to identify potential hazards, prioritise chemicals and other potentially toxic substances, and provide the data for assessing risk. However, recent advances in non-animal alternatives have led to significant changes in the recommended approaches to chemical safety assessment. Assessing the hazard and risk of a range of active ingredients, wca routinely conduct extensive literature reviews, read across and Quantitative Structure Activity Relationships (QSAR). In addition to international test guidelines, wca have extensive experience in non-animal in silico and in vitro testing batteries that aim to elucidate the mechanism and mode of toxicity.
Examples of projects:
- Toxicological review and data gap assessment of complex inorganic pigments
- Toxicological Risk Assessment of leachables and extractables in MDI components
- Toxicity profile of polychlorinated dibenzodioxins (PCDD), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs)
- Toxicological support to 2018 REACH registrations