March 15, 2016 by Owen Green & Ed Stutt
Two wca principal consultant are attending the Society of Toxiolcogy Annual Meeting and ToxExpo at the New Orleans Ernest N. Morial Convention Center and their round-up of Day 1 is detailed.
The Ernest N. Morial Convention Center
Owen attended a workshop session on dietary exposures to heterocyclic amines as a potential risk factor for neurological disease and the associated poster session on Neurotoxicity.
The workshop reported on the most recent investigations into the growing association between exposure to heterocyclic aromatic amines (HAAs) and the occurrence of neurodegenerative diseases. HAAs are encountered in a variety of foods, notably cooked meats and drinks. High temperature cooking and charring can produce several toxic compounds including HAAs which have been linked to various forms of cancer. It has been shown that HAAs affect dopamine metabolism and specific HAAs have been linked to essential tremor and more recently, Parkinson’s Disease. This workshop focused on newly emerging data suggesting a potential role of HAAs in neurological diseases and the data presented by the speakers demonstrated that HAA blood levels are associated with essential tremor and PD and that in vitro and in vivo treatments are selectively toxic to dopaminergic neurons. The four presentations covered clinical studies of neurology, in vitro and in vivo modelling of neurotoxicity, analytical/transport/PhIP quantification/pharmacokinetic assessment in biological fluids and tissues and biomarkers of exposure and adduct formation
Ed attended a platform session on lifecycle assessment for exposure to nano-particles and a workshop on the toxicological effects that resulted from the BP Deepwater Horizon oil spill. The oil spill in the Gulf of Mexico had a major impact on US Gulf states and especially Louisiana, as it significantly impacted the local seafood industry as well the people involved in the response to the incident. Dr Linda Birnbaum (Director of NIEHS) presented on an epidemiological follow-up study looking at health effects in response workers and Cornelius Elferink talked about the levels of petrogenic PAHs in seafood before and after the clean-up operation.
Inside the conference hall
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